Computational Microscopy, Sensing and Diagnostics
Friday, December 6, Giedt 1003, 12:10pm-1:00pm
Speaker: Dr. Aydogan Ozcan
University of California, Los Angeles
Host: Professor Erkin Seker
My research focuses on the use of computation/algorithms to create new optical microscopy, sensing, and diagnostic techniques, significantly improving existing tools for probing micro- and nano-objects while also simplifying the designs of these analysis tools. In this presentation, I will introduce a new set of computational microscopes which uses lens-free on-chip imaging to replace traditional lenses with holographic reconstruction algorithms. Basically, 3D images of specimens are reconstructed from their "shadows" providing considerably improved field-of-view (FOV) and depth-of-field, thus enabling large sample volumes to be rapidly imaged, even at nanoscale. These new computational microscopes routinely generate >1–2 billion pixels (giga-pixels), where even single viruses can be detected with a FOV that is >100 fold wider than other techniques. At the heart of this leapfrog performance lie self-assembled liquid nano-lenses that are computationally imaged on a chip. These self-assembled nano-lenses are stable for >1 hour at room temperature, and are composed of a biocompatible buffer that prevents nano-particle aggregation while also acting as a spatial “phase mask.” The field-of-view of these computational microscopes is equal to the active-area of the sensor-array, easily reaching, for example, >20 mm2 or >10 cm2 by employing state-of-the-art CMOS or CCD imaging chips, respectively.
In addition to this remarkable increase in throughput, another major benefit of this technology is that it lends itself to field-portable and cost-effective designs which easily integrate with smartphones to conduct giga-pixel tele-pathology and microscopy even in resource-poor and remote settings where traditional techniques are difficult to implement and sustain, thus opening the door to various telemedicine applications in global health. Some other examples of these smartphone-based biomedical tools that I will describe include imaging flow cytometers, immunochromatographic diagnostic test readers, bacteria/pathogen sensors, blood analyzers for complete blood count, and allergen detectors. Through the development of similar computational imagers, I will also report the discovery of new 3D swimming patterns observed in human and animal sperm. One of this newly discovered and extremely rare motion is in the form of “chiral ribbons” where the planar swings of the sperm head occur on an osculating plane creating in some cases a helical ribbon and in some others a twisted ribbon. Shedding light onto the statistics and biophysics of various micro-swimmers’ 3D motion, these results provide an important example of how biomedical imaging significantly benefits from emerging computational algorithms/theories, revolutionizing existing tools for observing various micro- and nano-scale phenomena in innovative, high-throughput, and yet cost-effective ways.
Dr. Aydogan Ozcan received his Ph.D. degree at Stanford University Electrical Engineering Department. After a short post-doctoral fellowship at Stanford University, he is appointed as a research faculty at Harvard Medical School, Wellman Center for Photomedicine in 2006. Dr. Ozcan joined UCLA in the summer of 2007 as an Assistant Professor, and was promoted to Associate and Full Professor ranks in 2011 and 2013, respectively. He is currently the Chancellor’s Professor at UCLA leading the Bio- and Nano-Photonics Laboratory at the Electrical Engineering and Bioengineering Departments, and is also the Associate Director of the California NanoSystems Institute (CNSI) at UCLA.
Dr. Ozcan holds 22 issued patents (all of which are licensed) and more than 15 pending patent applications for his inventions in nanoscopy, wide-field imaging, lensless imaging, nonlinear optics, fiber optics, and optical coherence tomography. Dr. Ozcan gave more than 150 invited talks and is also the author of one book, the co-author of more than 350 peer reviewed research articles in major scientific journals and conferences. In addition, Dr. Ozcan is the founder and a member of the Board of Directors of Holomic LLC.
Prof. Ozcan received several major awards including the 2011 Presidential Early Career Award for Scientists and Engineers (PECASE), which is the highest honor bestowed by the United States government on science and engineering professionals in the early stages of their independent research careers. Dr. Ozcan received this prestigious award for developing innovative optical technologies and signal processing approaches that have the potential to make a significant impact in biological science and medicine; addressing public health needs in less developed countries; and service to the optical science community including mentoring and support for underserved minority undergraduate and graduate students. Dr. Ozcan also received the 2013 SPIE BioPhotonics Technology Innovator Award, the 2011 Army Research Office (ARO) Young Investigator Award, 2011 SPIE Early Career Achievement Award, the 2010 NSF CAREER Award, the 2009 NIH Director’s New Innovator Award, the 2009 Office of Naval Research (ONR) Young Investigator Award, the 2009 IEEE Photonics Society Young Investigator Award and the MIT’s Technology Review TR35 Award for his seminal contributions to near-field and on-chip imaging, and telemedicine based diagnostics.
Prof. Ozcan is also the recipient of the Microscopy Today Innovation Award, Popular Science Brilliant 10 Award, National Academy of Engineering (NAE) The Grainger Foundation Frontiers of Engineering Award, Innovators Challenge Award presented by the Rockefeller Foundation and mHealth Alliance, the National Geographic Emerging Explorer Award, the Bill & Melinda Gates Foundation Grand Challenges Award, the Popular Mechanics Breakthrough Award, the Netexplorateur Award given by the Netexplorateur Observatory & Forum in France, the Wireless Innovation Award organized by the Vodafone Americas Foundation as well as the Okawa Foundation Award, given by the Okawa Foundation in Japan.
Prof. Ozcan was selected as one of the top 10 innovators by the U.S. Department of State, USAID, NASA, and NIKE as part of the LAUNCH: Health Forum organized in 2010. He also received the 2012 World Technology Award on Health and Medicine, which is presented by the World Technology Network in association with TIME, CNN, AAAS, Science, Technology Review, Fortune, Kurzweil and Accelerosity.
Dr. Ozcan is elected Fellow of SPIE and OSA, and is a Senior Member of IEEE, a Member of AAAS and BMES.
About the seminar:
This seminar is part of the Fall EEC 290 seminar series and is open to all.